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html. Skapa Stäng. Concomitant targeting of PD-1 or CD137 enhances the effect of adjuvant pro-inflammatory allogeneic dendritic cells. Pris: 1556 kr. inbunden, 2006. Skickas inom 5-7 vardagar.

Cd137

No binding was observed to CD137 − L-428-control cells (not shown). 137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. CD137 (4-1BB, TNFRSF9) is increasingly recognized as a pow-erful inducer of antitumor immune responses. The potency of CD137 co-stimulation in enabling the immune system to elimi-nate tumors has been documented in a wide plethora of murine tumor models including mastocytoma, sarcoma, colon carci- CD137 is a potent costimulatory receptor. Several agonistic anti‐CD137 antibodies are currently in clinical trials for tumor immunotherapy. Soluble forms of CD137 (sCD137) are generated by differential splicing and antagonize the activities of membrane‐bound CD137 (mCD137) and of therapeutic CD137 agonists.

Cd137 antigener. Medicinsk sök. Definitionerna

HVEM. CD27. CD137. GITR.

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OX40. CD28.

CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. Agonist monoclonal antibodies (mAb) to the immune costimulatory molecule CD137, also known as 4-1BB, are presently in clinical trials for cancer treatment on the basis of their costimulatory effects on primed T cells and perhaps other cells of the immune system. Here we provide evidence that CD137 is selectively expressed on the surface of tumor endothelial cells. Hypoxia upregulated CD137 on CD137-PE recognizes the CD137 (4-1BB) antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily. CD137 is mainly expressed on activated CD4 and CD8 tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T cells,inhibiting lymphocyte proliferation,activating apoptosis TNFRSF9 Phenotypes From GWAS Catalog for TNFRSF9 Gene CD137 is a costimulatory member of the TNF receptor superfamily that is expressed on a variety of immune cells following activation, including T cells, dendritic cells, and natural killer cells. Signaling via CD137 can lead to cytokine induction, prevention of activation-induced cell death, and
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137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. CD137 (4-1BB, TNFRSF9) is increasingly recognized as a pow-erful inducer of antitumor immune responses. The potency of CD137 co-stimulation in enabling the immune system to elimi-nate tumors has been documented in a wide plethora of murine tumor models including mastocytoma, sarcoma, colon carci- CD137 is a potent costimulatory receptor.

CD137, so CD137 mainly costimulates CD8+ T cells.16 Studies have shown that signaling through CD137 is induced by the ligand of CD137, CD137L, or by agonistic mAbs against CD137.
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It is a costimulatory member of the tumour necrosis receptor family and is reported to regulate T-cell activation and proliferation. CD137 protein is fully biologically active when compared to standard.

Farliga egenskaper - Cell Signaling Technology

Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. b CD137 mRNA expression in T-Rex/K-Ras cells incubated with various concentrations of IL-1α for 24 h. CD137 mRNA was measured by qTR-PCR. c CD137 mRNA expression in three human cancer cell lines incubated with 10 ng/mL IL-1α for 24 h. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD137 antibody (ab203391) Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue, labeling CD137 using ab203391 at a 1/600 dilution, followed by conjugation to the secondary antibody and DAB staining. CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family.

CD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. b CD137 mRNA expression in T-Rex/K-Ras cells incubated with various concentrations of IL-1α for 24 h.